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Figure 1 | Molecular Brain

Figure 1

From: Tristetraprolin expression and microRNA-mediated regulation during simian immunodeficiency virus infection of the central nervous system

Figure 1

Tristetraprolin mRNA expression during SIV infection. TTP was quantitated by TaqMan assay using total RNA isolated from thalamus of control, uninfected (‘0’) or SIV-infected macaques at different stages of infection and disease (A) and at the indicated number of days post-inoculation (B). Data were normalized by delta-deltaCt method, with 18S rRNA as the control, and graphed relative to the average expression of the control group. Bars represent mean (A) or median (B) fold change in each stage or at each time point. Shown for late-stage infection (B), CNS disease severity as determined by pathology examination is denoted by color: green = none, turquoise = mild, blue = moderate, red = severe. Inset: data sorted by stage of infection. Acute phase comprises days 4-10; persistent includes time points with lower viral load and cytokine expression (14 and 21); late-stage disease begins at day 42. ** denotes p < 0.01 by Kruskal-Wallis test with Dunn’s multiple comparison test.

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