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Table 1 Effect of 2 or 5 month STZ-diabetes on cytokine levels in rat DRG and sciatic nerve

From: Diabetes impairs an interleukin-1β-dependent pathway that enhances neurite outgrowth through JAK/STAT3 modulation of mitochondrial bioenergetics in adult sensory neurons

 

IL-1α

IL-1β

IL-10

IL-2

ssssssDRG

2 Months

   

Control

0.97 ± 0.1*

60.35 ± 15.4*

17.53 ± 6.0

4.53 ± 1.38

Diabetes

0.36 ± 0.05

28.38 ± 2.1

12.65 ± 3.6

2.63 ± 0.57

Sciatic nerve

    

Control

22.64 ± 7.3*

63.93 ± 18.2*

9.78 ± 3.5

3.09 ± 0.28

Diabetes

9.55 ± 3.7

34.05 ± 6.3

13.87 ± 7.1

4.98 ± 0.90

Tibial nerve

    

Control

25.0 ±1.7

102.4 ± 17.7*

31.79 ± 17.7

4.64 ± 3.04

Diabetes

19.46 ±9.5

45.41 ± 8.5

39.64 ± 3.9

6.12 ±2.53

DRG

5 Months

   

Control

1.99 ± 0.6*

75.7 ± 10.9*

ND

5.99 ± 2.93

Diabetes

0.68 ± 0.1

32.1 ± 5.2

ND

1.93 ± 0.63

Sciatic nerve

    

Control

15.9 ± 2.5*

64.15 ± 8.1*

ND

2.08 ± 0.77

Diabetes

3.6 ± 1.1

25.68 ± 5.3

ND

2.61 ± 1.15

Tibial nerve

    

Control

17.0 ± 2.46*

105.4 ± 14.8*

ND

3.81 ± 1.63

Diabetes

3.4 ± 1.02

30.74 ± 6.6

ND

3.25 ± 0.94

  1. Cytokine protein levels were determined using a Luminex machine with the BioRad 9-plex cytokine kit and are expressed in pg/mg total protein. A standard curve was generated for each cytokine and all values were derived from the linear aspect of the curve. Values are mean ± SD, n=4-6. *P<0.05 vs diabetic (Students t-Test).