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Table 1 Effect of 2 or 5 month STZ-diabetes on cytokine levels in rat DRG and sciatic nerve

From: Diabetes impairs an interleukin-1β-dependent pathway that enhances neurite outgrowth through JAK/STAT3 modulation of mitochondrial bioenergetics in adult sensory neurons

  IL-1α IL-1β IL-10 IL-2
ssssssDRG 2 Months    
Control 0.97 ± 0.1* 60.35 ± 15.4* 17.53 ± 6.0 4.53 ± 1.38
Diabetes 0.36 ± 0.05 28.38 ± 2.1 12.65 ± 3.6 2.63 ± 0.57
Sciatic nerve     
Control 22.64 ± 7.3* 63.93 ± 18.2* 9.78 ± 3.5 3.09 ± 0.28
Diabetes 9.55 ± 3.7 34.05 ± 6.3 13.87 ± 7.1 4.98 ± 0.90
Tibial nerve     
Control 25.0 ±1.7 102.4 ± 17.7* 31.79 ± 17.7 4.64 ± 3.04
Diabetes 19.46 ±9.5 45.41 ± 8.5 39.64 ± 3.9 6.12 ±2.53
DRG 5 Months    
Control 1.99 ± 0.6* 75.7 ± 10.9* ND 5.99 ± 2.93
Diabetes 0.68 ± 0.1 32.1 ± 5.2 ND 1.93 ± 0.63
Sciatic nerve     
Control 15.9 ± 2.5* 64.15 ± 8.1* ND 2.08 ± 0.77
Diabetes 3.6 ± 1.1 25.68 ± 5.3 ND 2.61 ± 1.15
Tibial nerve     
Control 17.0 ± 2.46* 105.4 ± 14.8* ND 3.81 ± 1.63
Diabetes 3.4 ± 1.02 30.74 ± 6.6 ND 3.25 ± 0.94
  1. Cytokine protein levels were determined using a Luminex machine with the BioRad 9-plex cytokine kit and are expressed in pg/mg total protein. A standard curve was generated for each cytokine and all values were derived from the linear aspect of the curve. Values are mean ± SD, n=4-6. *P<0.05 vs diabetic (Students t-Test).