The effect of Y1R antisense (or missense) pretreatment on daily AMPH-mediated food intake over a 4-day period. Daily missense or antisense treatment (20 μg/10 μl/day, i.c.v.) was administered one hour before daily AMPH treatment. * p < 0.05 vs. the missense groups. #p < 0.05 vs. the AMPH-treated groups of each treatment. Bars are the means ± SEM. N = 8 per group.