Figure 2From: Pharmacological enhancement of mGlu1 metabotropic glutamate receptors causes a prolonged symptomatic benefit in a mouse model of spinocerebellar ataxia type 1Appearance of mGlu5 receptors in Purkinje cells of symptomatic SCA1 mice. mGlu5 receptor mRNA and protein levels in the cerebellum of presymptomatic and symptomatic SCA1 mice (and their age-matched wild-type littermates) are shown in (A) and (B), respectively. Values are means ± S.E.M. of 4 mice per group. *p < 0.05 (Student’s t test) vs. the corresponding wild-type mice. t = 10 (densitometric analysis of immunoblots). Immunohistochemical analysis of mGlu5 receptors in the cerebellum of SCA1 mice and wild-type littermates are shown in (C) and (D). Confocal microscopy analysis of mGlu5 receptors in Purkinje cells of wild-type and symptomatic SCA1 mice is shown in (E). Note the somatic and perisomatic immunostaining which excludes the cell nucleus.Back to article page