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Table 1 Measurements of drug levels by HPLC/MS-MS in the cerebellum of symptomatic SCA1 mice at 30–120 min after a single injection of Ro0711401 (10 mg/kg, s.c.)

From: Pharmacological enhancement of mGlu1 metabotropic glutamate receptors causes a prolonged symptomatic benefit in a mouse model of spinocerebellar ataxia type 1

Time after injection

Cerebellar Ro0711401 levels

 

(pg/mg tissue)

30 min

211 ± 20

60 min

135 ± 10

90 min

100 ± 9

120 min

100 ± 40

240 min

80 ± 30

24 hours

N.D.

  1. Values are means ± S.E.M. of 3 animals per time point. N.D. = not detectable.
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Molecular Brain

ISSN: 1756-6606