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Table 1 Measurements of drug levels by HPLC/MS-MS in the cerebellum of symptomatic SCA1 mice at 30120 min after a single injection of Ro0711401 (10 mg/kg, s.c.)

From: Pharmacological enhancement of mGlu1 metabotropic glutamate receptors causes a prolonged symptomatic benefit in a mouse model of spinocerebellar ataxia type 1

Time after injection Cerebellar Ro0711401 levels
  (pg/mg tissue)
30 min 211 ± 20
60 min 135 ± 10
90 min 100 ± 9
120 min 100 ± 40
240 min 80 ± 30
24 hours N.D.
  1. Values are means ± S.E.M. of 3 animals per time point. N.D. = not detectable.