Figure 2

Potentiation of zinc toxicity by angiotensin II is specific to neurons. A) Bars denote LDH release (mean ± SEM, n = 7) in near-pure neuronal cultures after 15 min exposure to 300 μM zinc or zinc plus 0.5, 1, or 50 μM angiotensin II (*p < 0.05, **p < 0.01 versus zinc alone; two-tailed t-test). B) LDH release (mean ± SEM, n = 7) in astrocytic cultures after 15 min exposure to 300 μM zinc or zinc plus the indicated concentrations of angiotensin II.