Figure 4
From: Changes of peripheral TGF-β1 depend on monocytes-derived macrophages in Huntington disease
NF-κB -p65 protein expression is increased in macrophages from preHD subjects. A, Representative immunoblot (left) and densitometric analysis (right) of NF-κB -p65 expression in healthy controls (CTRL, n = 5), pre-manifested subjects (pre-HD, n = 5) and severe HD patients (HD, n = 5). Bars represent the mean values ± s.d *p < 0.05 (ANOVA, Tukey post-hoc test). B, Representative microphotographs showing NF-κB -p65 immunoreactivity on formalin-fixed and paraffin-embedded post-mortem striatal tissues from control subjects (CTRL) and HD patients at different neuropathological grades (Grade I, II, III, IV).