Figure 2

The preliminary cDNA array experiment. (A) Venn diagrams that illustrate the distribution of altered transcripts in the striatum. The diagrams are derived from the gene expression data of the cDNA array data (preliminary experiment). The red circle or blue circle contains the genes that exhibited increased or decreased expressions more than 1.3-fold or less than 0.7-fold compared with saline-injected control mice, respectively. The numbers in parentheses show the number of changed transcripts in each group. WPCP, PCP-injected WT mice; WS, saline-injected WT mice; KOS, saline-injected GluN2D KO mice; KOPCP, PCP-injected GluN2D KO mice. (B) Scatter plot of the effect of PCP on gene expression in WT mice (X-axis) and GluN2D KO mice (Y-axis). The scatter plot of all of the transcripts shows the ratios between the expression of each gene in WPCP and the expression of each gene in WS and the ratios between the expression of each gene in KOPCP and the expression of each gene in KOS. Each point shows the fold-change (%) using the cDNA array data (preliminary experiment), which included globally normalized data. The associations between the parameters were analyzed using Karl Pearson’s correlation or Spearman’s rank correlation. Gene expression in WPCP was negatively correlated with gene expression in KOPCP (r = −0.564, p < 0.01).