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Table 1 Genotype frequencies

From: Combined analysis of circulating β-endorphin with gene polymorphisms in OPRM1, CACNAD2 and ABCB1 reveals correlation with pain, opioid sensitivity and opioid-related side effects

Gene

SNP

High responder

Normal responder

Non responder

Control

  

N=16

N=44

N=20

N=56

OPRM1

A>G

44% N=7

22% N=8

25% N=5

25% N=14

ABCB1

C>T

32% N=5

27% N=12

25% N=5

34% N=19

CACNA2D2

G>A

0% N=0

27% N=12

30% N=6

25% N=14

  1. Percentage of minor alleles of the OPMR1, ABCB1, and CACNA2D2 genes in high-, normal, non-responders and in control subjects. Due to the low frequency of the GG allele of OPRM1, the minor allele was defined as the combined AG/GG alleles. For further details see Methods and Results.
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Molecular Brain

ISSN: 1756-6606