Figure 10

Prolonged steady depolarization worsens the time-dependent infidelity of spike propagation on the main axons of cerebellar Purkinje cells. A) shows spikes recorded on axonal bleb (top trace), somatic spikes induced by a train of depolarization pulse at 100 Hz (bottom) and dV/dt values of somatic spikes (middle). B) illustrates spikes recorded on axonal blebs (top trace), somatic spikes induced by a prolonged steady depolarization pulse (bottom) and dV/dt values of somatic spikes, in which spike’s frequency reaches to 100 Hz. Red arrows indicate the failure of spike propagation. Calibration bars are 0.2 mV for axonal spikes, 10 mV for whole-cell spikes, 20 mV/ms for dV/dt and 50 ms. C) illustrates propagation fidelity (a ratio of axonal spikes to somatic ones) versus spiking time by giving steady depolarization (red symbols) and depolarization pulses (black symbols). D) illustrates maximal dV/dt versus spiking time by giving steady depolarization (red symbols) and depolarization pulses (black symbols).