Figure 11

Prolonged steady depolarization worsens the time-dependent deceleration of spike propagation on the main axons of cerebellar Purkinje cells. A) illustrates the spikes on axons (top traces) and dV/dt of somatic spikes (bottom traces) in initial (red), middle (green) and late phases (blue) induced by a train of depolarization pulses at 100 Hz. B) shows the spikes on axons (top traces) and dV/dt of somatic spikes (bottom traces) in initial (red), middle (green) and late phases (blue) induced by a prolonged steady depolarization. Traces in different colors are taken from the boxes in 10A ~ B with corresponding colors. Calibration bar is 0.5 ms. C) illustrates the normalized velocity of spike propagation vs. spiking time by giving a steady depolarization (red symbols) and a train of depolarization pulses (black symbols).