Figure 4

Propagation failure of a spike makes the propagation deceleration of subsequent spike partially recovered. A) Top trace shows axonal spikes, and bottom trace shows dV/dt values of somatic spikes. A comparison of peak time indicates a sequence that spike propagation slows down, spike propagation fails and spike propagation velocity recovers. B) shows normalized velocity of spike propagation versus time at 200 Hz of sequential spikes. The velocity of spike propagation decreases to two levels, i.e., initial level one (blue dash line) and subsequent level two (purple). Red vertical bars show the time points of spike propagation failure. C) shows normalized velocity of spike propagation vs. time, which was taken from B) in corresponding time. A decrease in spike propagation velocity is followed by loss of spikes during their propagation and a subsequent propagation velocity recovery (blue lines). D) illustrates the normalized velocity of spike propagation before and after spike propagation failure, i.e., the recovery of spike propagation deceleration. Two asterisks indicate p < 0.01.