Figure 7

Afterhyperpolarization (AHP) improves a time-dependent deceleration of spike propagation on the main axons of cerebellar Purkinje cells. A ~ B) shows the spikes on axons (top traces) and dV/dt of somatic spikes (bottom traces) in initial (red), middle (green) and late phases (blue) under conditions of control (A) and biphasic pulses (B). The traces in different colors are taken from the boxes in 6A ~ B with corresponding colors. C) illustrates the normalized velocity of spike propagation versus time at 200 Hz of spikes under controls. The velocity of spike propagation decreases to two levels, level one (blue dash line) and level two (purple). Red vertical bars illustrate the time points of spike propagation failure. D) shows the normalized velocity of spike propagation vs. time at 200 Hz of spikes when biphasic pulses (AHP) is given. E) shows the normalized velocity of spike propagation vs. somatic spiking time under the conditions of control (black symbols) and biphasic pulses (reds; asterisks, p < 0.01; n = 9).