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Figure 3 | Molecular Brain

Figure 3

From: Vps35 haploinsufficiency results in degenerative-like deficit in mouse retinal ganglion neurons and impairment of optic nerve injury-induced gliosis

Figure 3

Reduced RGC axon fibers in P30 vps35+/mretinas. (A-B) Immunostaining analysis using anti-neurofilament antibodies of flat-mounted retinas (A) and cross sections (B) from P30 Vps35+/+ and +/m mice. In A, the bottom two panels are amplified images from the marked squares in upper panel. OD: optic disc; NF: nerve fiber. (C) Immunostaining analysis using anti-Tuj1antibodies of flat-mounted retinas from P30 Vps35+/+ and +/m mice. Scale bars in A-C, 50 μm. (D) Quantification analysis of the ratio of nerve fibers verse RGC somas stained by anti-Tuj1. (E) Quantification analysis of RGC soma density. In (D-E), mean +/- SEM (n = 5 retinas) were shown. *, P < 0.05.

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Molecular Brain

ISSN: 1756-6606