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Figure 4 | Molecular Brain

Figure 4

From: Vps35 haploinsufficiency results in degenerative-like deficit in mouse retinal ganglion neurons and impairment of optic nerve injury-induced gliosis

Figure 4

Disturbed RGC dendrites in P20 vps35+/mretinas. (A) Immunostaining analysis using anti-Tuj1 antibodies of cross-sections of retinas from vps35+/+ and +/m mice at indicated ages. Inserts are amplified images of the marked squears. GCL, ganglion cell layer; NL, neuroblast layer; IPL, inner plexiform layer; INL, inner nuclear layer; OPL, outer plexiform layer; ONL, outer nuclear layer; OS, outer segment; IS, inner segment. Arrows indicate co-localization signals. Inserts are amplified images of the marked squares. Scale bar, 50 μm. (B) Quantification analysis of the fluorescence intensity in RGC dendrites marked by anti-Tuj1. The values of mean +/- SEM (n = 5 retinas) were shown. *, P < 0.05. (C) Western blot analysis of Tuj1 expression in retina homogenates from vps35+/+ and +/m at indicated ages.

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Molecular Brain

ISSN: 1756-6606