DMS alleviates anxiety-associated defects and extend life span in mouse model for Rett syndrome. (A) Time spent in light compartment during light–dark transition tests. Values represent mean (±) SEM (Animal amounts, wt n = 8, mecp2308/y n = 9, mecp2308/y + DMS n = 9; **: P < 0.005, *: P < 0.05, two-tailed student’s t-test). (B) Times of light–dark transitions during test. Values represent mean (±) SEM (*: P < 0.05, two-tailed student’s t-test). (C) Kaplan-Meier survive curve of nestin-cre, mecp2flox/y mice with control, DMS with P1 and P5 treatments, respectively. (n = 4 for each condition).