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Table 2 Pharmacological profile of SM-345431 (part 2)

From: Rewiring of regenerated axons by combining treadmill training with semaphorin3A inhibition

Kinases IC50 (μm)
CaMKII >10
CDK5/p35 >10
cSRC >10
EGFR 0.90
EphA2 >10
EphA4 0.80
EphB2 0.68
EphB4 >10
Fes >10
FGFR1 >10
FGFR2 >10
FGFR3 0.77
FGFR4 0.64
Flt1 >10
Flt3 >10
Fyn >10
GSK3α 2.46
GSK3β >10
IGF-1R >10
JAK3 >10
KDR >10
MAPK2 >10
MEK1 >10
MEK4 >10
MKK6 >10
PAK2 >10
PAK4 >10
PKA >10
PKBα >10
PKBβ >10
PKCγ >10
ROCK-I >10
ROCK-II >10
ROCK-II >10
SAPK2a >10
TrkA >10
TrkB >10
PI 3-Kγ >10
  1. Summary of the IC50 values revealed by inhibition tests for various kinases. The data in Tables 1 and 2 suggest that SM-345431 was highly selective for semaphorin3A inhibition.