Table 2 Pharmacological profile of SM-345431 (part 2)
From: Rewiring of regenerated axons by combining treadmill training with semaphorin3A inhibition
Kinases | IC50 (μm) |
|---|---|
CaMKII | >10 |
CDK5/p35 | >10 |
cSRC | >10 |
EGFR | 0.90 |
EphA2 | >10 |
EphA4 | 0.80 |
EphB2 | 0.68 |
EphB4 | >10 |
Fes | >10 |
FGFR1 | >10 |
FGFR2 | >10 |
FGFR3 | 0.77 |
FGFR4 | 0.64 |
Flt1 | >10 |
Flt3 | >10 |
Fyn | >10 |
GSK3α | 2.46 |
GSK3β | >10 |
IGF-1R | >10 |
JAK3 | >10 |
KDR | >10 |
MAPK2 | >10 |
MEK1 | >10 |
MEK4 | >10 |
MKK6 | >10 |
PAK2 | >10 |
PAK4 | >10 |
PKA | >10 |
PKBα | >10 |
PKBβ | >10 |
PKCγ | >10 |
ROCK-I | >10 |
ROCK-II | >10 |
ROCK-II | >10 |
SAPK2a | >10 |
TrkA | >10 |
TrkB | >10 |
PI 3-Kγ | >10 |