Figure 2
Decreased anxiety-like behaviors in Apc1638T/1638Tmice. (A-D) Light/dark transition test: (A) distance traveled in the light/dark compartments, (B) time stayed in the light compartment, (C) number of light/dark transitions, and (D) latency to enter the light compartment were recorded. (E-H) Elevated plus maze: (E) number of arm entries, (F) percentage of entries into the open arms, (G) distance traveled, and (H) percentage of time spent on open arms were recorded. (I-K) Contextual and cued fear conditioning test: (I) percentage of time freezing during conditioning (genotype effect, F1,37 = 47.089, p < 0.0001; genotype × time interaction, F7,259 = 10.618, p < 0.0001), (J) percentage of time freezing during contextual testing (genotype effect, F1,37 = 14.438, p = 0.0005), and (K) percentage of time freezing during cued testing were recorded (genotype effect, F1,37 = 75.104, p < 0.0001). During the time indicated by the horizontal bold lines, tone stimuli were given. Arrows indicate the time points of foot shock stimuli. The p values in the figure indicate genotype effect in one-way ANOVA (A-H) or two-way repeated measures ANOVA (I-K). Error bars indicate SEM.