Figure 5
Impaired learning and memory in Apc1638T/1638Tmice. (A-C) Barnes circular maze test: (A) latency to reach the target hole (genotype effect, F1,37 = 5.974, p = 0.0194) and (B) number of errors before reaching the target hole across training sessions (genotype effect, F1,37 = 4.904, p = 0.033) were recorded. (C) Time spent around each hole in the probe trial conducted 24 hours after the last training session was recorded. (D and E) Eight-arm radial maze test: (D) different arm choices among the first eight entries (genotype effect, F1,35 = 36.684, p < 0.0001; genotype × block of trials interaction, F16,560 = 3.109, p < 0.0001), and (E) total number of arms revisited during training (genotype effect, F1,35 = 16.947, p = 0.0002; genotype × block of trials interaction, F16,560 = 2.768, p = 0.0003) were recorded. The p values in the figure indicate genotype effect in two-way repeated measures ANOVA (A, B, D, E) or one-way ANOVA (C). Error bars indicate SEM.