Targeted deletion of the C-terminus of the mouse adenomatous polyposis coli tumor suppressor results in neurologic phenotypes related to schizophrenia

Table 1 Abnormal amounts of monoamines and their metabolites in the brain of Apc ^1638T/1638T mice

Brain region	Genotype		Norepinephrine	DOPAC	HVA	5-HIAA
Brain region	Genotype		pmol/mg protein
Midbrain	Apc ^+/+	(n = 6)	13.4 ± 0.8	5.46 ± 0.42	9.21 ± 0.93	58.8 ± 2.6
Midbrain	Apc ^1638T/1638T	(n = 6)	29.5 ± 1.8****	7.57 ± 0.65*	11.4 ± 1.19	78.7 ± 4.9***
Pons-medulla	Apc ^+/+	(n = 6)	10.7 ± 0.6	1.34 ± 0.15	2.13 ± 0.36	29.4 ± 1.5
Pons-medulla	Apc ^1638T/1638T	(n = 6)	23.9 ± 1.1****	2.13 ± 0.16***	2.77 ± 0.33	37.2 ± 1.9**
Striatum	Apc ^+/+	(n = 6)	nd	113 ± 6.0	76.9 ± 3.9	20.9 ± 0.9
Striatum	Apc ^1638T/1638T	(n = 6)	nd	173 ± 7.6****	94.3 ± 5.5*	24.7 ± 1.9
Frontal cortex	Apc ^+/+	(n = 6)	8.48 ± 0.69	2.74 ± 0.75	5.16 ± 0.87	11.8 ± 0.5
Frontal cortex	Apc ^1638T/1638T	(n = 6)	2.62 ± 0.34****	3.53 ± 0.64	6.04 ± 0.70	9.78 ± 0.76*
Hippocampus	Apc ^+/+	(n = 6)	10.1 ± 0.6	1.21 ± 0.18	3.11 ± 0.24	27.9 ± 3.0
	Apc ^1638T/1638T	(n = 6)	2.42 ± 0.29****	1.52 ± 0.16	4.09 ± 0.40	22.1 ± 1.5

Amounts of monoamines and their metabolites are expressed as pmol/mg protein. Values are the means ± SEM. nd: not detected, DOPAC: dihydroxyphenylacetic acid, HVA: homovanillic acid, 5-HIAA: 5- hydroxyindolacetic acid. *p < 0.05, **p < 0.01, ***p < 0.005, ****p < 0.001.

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