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Figure 3 | Molecular Brain

Figure 3

From: iPS cell technologies: significance and applications to CNS regeneration and disease

Figure 3

Strategies for the development of iPS cell-based cell therapy for SCI patients. Our collaborative team (Okano’s group at Keio University and Yamanaka’s group at Kyoto University) have been developing an iPS cell-based cell therapy for SCI since 2006. Our previous preclinical studies have shown that long-term functional restoration can be obtained by transplantation of NS/PCs derived from appropriate iPS cells clones without observable tumor formation [10]. Currently, we aim to develop iPS cells-based cell therapy for SCI patients at sub-acute phase using the clinical grade iPS cell-derived NS/PCs (i.e., the role of Okano’s group described in the blue box) which have been prepared from human iPS cell stock (i.e., the role of Yamanaka’s group described in the yellow box).

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