iPS cell technologies: significance and applications to CNS regeneration and disease

Table 2 Representative reports on neurological/psychiatric disorders

*Name of disease*	*Gene responsible*	*Cells responsible for pathogenesis*	*References*
		Neurodevelopmental disorders
Rett syndrome	MeCP2, CDK5L5	Neurons, neural precursors	[63]
Spinomuscular atrophy	SMN1	Motor neurons	[49]
Familial dysautonomia	IKBKAP	Neural crest precursor cells	[64]
Fragile X-syndrome	FMR1	Neurons	[62]
Adrenoleuko- dystrophy	ABCD1	Oligodendrocytes	[66]
Pelizaeus- Merzbacher disease	PLP1	Oligodendrocytes	[65]
Dravet syndrome	SCN1A	Neurons	[70–72]
		Late-onset neurodegenerative disorders
Alzheimer’s disease	PS1, PS2, APP, sporadic	Neurons	[52, 53, 58, 100]
Parkinson’s disease	α-synuclein, PARKIN, PINK-1, LRRK2 etc. sporadic	Dopaminergic neurons	[55–59, 83, 87]
Amyotrophic lateral sclerosis	SOD1, TDP43, FUS, C9ORF etc. sporadic	Motor neurons, astroglia	[47–49]
Spinobulbar muscular atrophy	Androgen receptor	Motor neurons, skeletal muscles	[50]
Huntington’s disease	HTT	Glutamatergic neurons, GABAergic neurons	[59, 60]
Machado-Joseph disease	ATX3	Glutamatergic neurons	[61]
		Psychiatric disorders
Schizophrenia	22q11.2, sporadic	Glutamatergic neurons, GABAergic neurons, dopaminergic neurons, etc.	[67–69]

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