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Figure 6 | Molecular Brain

Figure 6

From: Input-dependent subcellular localization of spike initiation between soma and axon at cortical pyramidal neurons

Figure 6

Pre-depolarization inactivates voltage-gated sodium channels (VGSC) partially and weakens their subsequent activation at the axon. A-B) Pre-depolarization pulses inactivate VGSCs mainly at the axons (A). The inactivation curve of axonal VGSCs (blue symbols in B) is on the left side of that of somatic ones (red triangles). Axonal VGSCs are more easily inactivated. C-D) A pre-depolarization pulse weakens somatic VGSCs activation slightly (top panel in C for waveform and red-filled symbols in D) compared with control (bottom panel in C and opens in D). E-F) A pre-depolarization pulse significantly weakens axonal VGSCs activation (top panel in E for waveform and blue-filled symbols in F) compared with control (bottom in E and opens in F).

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Molecular Brain

ISSN: 1756-6606