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Figure 8 | Molecular Brain

Figure 8

From: Input-dependent subcellular localization of spike initiation between soma and axon at cortical pyramidal neurons

Figure 8

ATX dominantly secures the axonal capability of firing sequential spikes induced by long-time steady depolarization pulses. A) shows a diagram for whole-cell recording at the soma and axon, and puffing 5 μM ATX (green pipette) toward axonal bleb. B) Long-time steady pulse initiates sequential spikes at the axon of cortical pyramidal neurons before (blue trace) and after ATX application (green), as well as sequential spikes at the soma of pyramidal neurons (red trace). C) shows spikes per second versus stimulus intensities at the axons of pyramidal neuron before (blue circles) and after ATX applications (greens, n = 10; asterisks, p < 0.05), as well as input–output curves at the somatic recordings (red triangles; n = 10).

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