No requirement of TRPV1 in long-term potentiation or long-term depression in the anterior cingulate cortex

Liu, Ming-Gang; Zhuo, Min

doi:10.1186/1756-6606-7-27

Molecular Brain

Table 2 Summary of previous studies on TRPV1 and synaptic plasticity in the brain

From: No requirement of TRPV1 in long-term potentiation or long-term depression in the anterior cingulate cortex

Brain area	Species	Method	Plasticity type	Key findings	Reference
Hippocampus	Mouse	fEPSP	LTP	Reduced LTP in the CA1 region in TRPV1-deficient mice	[21]
CA1 region				Reduced LTP in the CA1 region in TRPV1-deficient mice	[21]
Hippocampus	Rat	fEPSP	LTP and LTD	TRPV1 agonists facilitated LTP but suppressed LTD induction and thus antagonized the stress effect on synaptic plasticity in the CA1 region	[22]
CA1 region					[22]
Hippocampus	Rat	fEPSP	LTP and LTD	TRPV1 activation facilitates LTP induction via disinhibition, reduces DHPG-induced acute depression, but does not affect LFS-induced LTD in CA1	[31]
CA1 region					[31]
Hippocampus	Rat	EPSC	LTD	TRPV1 channels activated by 12-(S)-HPETE mediate a presynaptic form of LTD in the excitatory synapses on CA1 interneurons	[24]
CA1 region					[24]
Hippocampus	Rat	EPSC	LTD	Calcineurin is required for TRPV1-induced LTD in the CA1 interneurons	[32]
CA1 region					[32]
Hippocampus	Mouse	fEPSP and EPSC	LTP and LTD	Loss of interneuron LTD and attenuated pyramidal cell LTP in the TRPV1 knockout mice	[23]
CA1 region					[23]
Dentate gyrus	Rat and mouse	EPSC	LTD	TRNPV1 channels activated by anandamide mediate a postsynaptic form of LTD in dentate granular cells	[25]
Superior colliculus	Mouse	fEPSP	LTD	TRPV1 channels mediate LTD in the developing superior colliculus	[33]
Nucleus accumbens	Mouse	EPSC	LTD	TRPV1 channels activated by endocannabinoid mediate a postsynaptic form of LTD in medium spiny neurons of the indirect pathway	[26]
BNST and dorsal striatum	Rat	fEPSP and EPSC	LTD	TRPV1 channels activated by anandamide mediate LTD in the BNST but not dorsal striatum	[34]
Lateral amygdala	Mouse	fEPSP	LTP	TRPV1 agonist affected the LTP in a way that is dependent on the anesthetic	[35]
ACC	Mouse	fEPSP	LTP and LTD	TRPV1 antagonosts had no effect on cingulate LTP or LTD induction	The present study

Notes: 12-(S)-HPETE, 12(S)-hydroperoxyeicosa-5Z, 8Z, 10E, 14Z-tetraenoic acid; ACC, anterior cingulate cortex; BNST, bed nucleus of the stria terminalis; DHPG, (RS)-3,5-dihydroxy phenylglycine; EPSC, excitatory postsynaptic current; fEPSP, field excitatory postsynaptic potential; LFS, low-frequency stimulation; LTD, long-term depression; LTP, long-term potentiation; TRPV1, transient receptor potential vanilloid type 1.

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ISSN: 1756-6606

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