Alterations in neurological deficits in mechanical sensitivity to von Frey filaments after spinal cord ischemia reperfusion (I/R) injury. The significant decreases relative to baseline in withdrawal threshold (WT) on postoperative 8 h to 36 h in I/R group, suggesting that spinal cord I/R injury induced mechanical hyperalgesia in the paws. Continuous intrathecal administration of minocycline, TAK-242 and pyrrolidine dithiocarbamate (PDTC) for 3 days before the surgical operation increased the withdrawal threshold at time points 8, 12, 24, and 36 h compared to the I/R group. Intrathecal administration of LPS synergistically enhanced the mechanical hyperalgesia. **P < .01 compared to Sham group; ##P < .05 compared to I/R group in one-way analysis of variance followed by Tukey’s test (n = 12 per group).