Figure 1

Extinction training upregulates Arc expression in the BLA. (A) The Extinction group underwent contextual fear conditioning and extinction training, in which they were re-exposed to the conditioning context for 40 min without shock. The No Extinction group underwent fear conditioning but not extinction training. (B) Representative images of Arc-immunolabeled cells in the Extinction and No Extinction groups, respectively. (C) The Extinction group demonstrated more Arc-labeled cells relative to the No Extinction group in both BA and LA (n = 6 mice per group, **p < 0.01).