Figure 3

Inhibiting Arc translation in the BLA impairs long-term extinction of conditioned fear. (A) Mice received intra-BLA infusions of either Arc antisense or scrambled ODN 3 h before extinction training, and were subjected to short-term (STM) and long-term memory (LTM) tests 2 h and 24 h later, respectively. (B) Freezing time during extinction training decreased over time. The mice that received antisense ODN had a longer freezing period versus the mice that received scrambled ODN in the LTM test, but not the STM test (n = 14 mice per group, **p < 0.01). (C) Histological verification of cannula placements for mice infused with Arc antisense or scrambled ODN.