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Figure 7 | Molecular Brain

Figure 7

From: Chronic stress impairs GABAergic control of amygdala through suppressing the tonic GABAA receptor currents

Figure 7

Chronic stress leads to substantial impairment of GABAergic inhibition onto neuronal excitability in lateral amygdala (LA). A, B, The GABAergic modulation of neuronal excitability in LA from control mice. (A) shows the firing pattern of a single LA neuron in response to a depolarizing current pulse of 100 pA when the slices are perfused with ACSF (upper), GABA (middle) and BIC (bottom) successively. (B) shows the number of action potential increases steadily with the increase of pulse amplitude. Bath application of GABA causes a substantial decrease of the action potential number at any given pulse amplitude, which is completely reversed by subsequent BIC application. C, D, The GABAergic modulation of neuronal excitability in LA from CIS mice. The ability of GABA to suppress the neuronal firing in CIS mice is much weaker relative to that in control mice. The other illustrations are the same as in (A-B). E, F, The GABAergic modulation of neuronal excitability in LA from metyrapone-pretreated CIS mice. Metyrapone pretreatment improves the impaired GABAergic control over neuronal excitability in LA from CIS mice. The other illustrations are the same as in (A-B). *p < 0.05; **p < 0.01; ***p < 0.001.

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