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Figure 1 | Molecular Brain

Figure 1

From: Chronic brain inflammation causes a reduction in GluN2A and GluN2B subunits of NMDA receptors and an increase in the phosphorylation of mitogen-activated protein kinases in the hippocampus

Figure 1

Performance of aCSF- and LPS-infused rats in the spatial version of a Morris water maze. (A) Search error in finding a hidden platform in a spatial learning task during 5 training trial blocks. The artificial cerebrospinal fluid (aCSF)-infused rats (labeled as aCSF) became proficient at locating the submerged platform during training. The lipopolysaccharide (LPS)-infused rats (labeled as LPS) showed less improvement over the course of training when compared with the aCSF-infused rats (*, p < 0.05). (B) The percentage of time spent in the target annulus which was 5 times of the platform size, during the 30 s probe trial. The aCSF-infused rats spent more time in the target area than the LPS-infused rats, and this was statistically significant at the third probe trial (*, p < 0.05).

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Molecular Brain

ISSN: 1756-6606