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Figure 4 | Molecular Brain

Figure 4

From: Chronic brain inflammation causes a reduction in GluN2A and GluN2B subunits of NMDA receptors and an increase in the phosphorylation of mitogen-activated protein kinases in the hippocampus

Figure 4

Confocal photomicrographs of dual staining for p-Erk1/2 and markers of cellular location in the CA1, CA3, and DG of the aCSF- and LPS-infused rats. Photomicrographs showed the overlap between p-Erk1/2-positive signals and NeuN, a neuronal marker (A), or CD11b, a microglial marker (B), or GFAP, an astrocyte marker (C). The p-Erk1/2-positive cells were observed mostly in neurons and also in microglia or astrocytes. No differences between the LPS- and the aCSF-infused rats were observed in p-Erk1/2 levels expressing in the CD11b-positive microglia of the hippocampus (D). Levels of p-Erk1/2 expressing in the GFAP-positive astrocyte were significantly increased in the hippocampal CA1, CA3, and DG areas of the LPS-infused rats compared with the aCSF-infused rats (E). *, p < 0.01.

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