Skip to main content
Figure 5 | Molecular Brain

Figure 5

From: Analysis of rare variations reveals roles of amino acid residues in the N-terminal extracellular domain of nicotinic acetylcholine receptor (nAChR) alpha6 subunit in the functional expression of human alpha6*-nAChRs

Figure 5

Variations in nAChR hα6 subunit influence the current responses of hα6hβ4-nAChRs. Mean (±SE) peak inward current responses upon exposure to 100 μM nicotine (5 sec exposure; ordinate) are estimated from oocytes (n = 6-9) voltage clamped at −70 mV and heterologously expressing the indicated nAChR subunits. Oocytes coexpressing hα6A184D (variation in loop D) and hβ4 subunits yield largest current responses to 100 μM nicotine. Comparisons of peak current responses between control (hα6hβ4-nAChR) and variant groups were analyzed using one-way ANOVA with Dunnett’s multiple comparisons test (*, p < 0.05; and **, p < 0.01).

Back to article page

Molecular Brain

ISSN: 1756-6606