From: Block of T-type calcium channels by protoxins I and II
A | |||||
---|---|---|---|---|---|
Clone | Current block (%) ProTx II (1 μM) | V0.5act (mV) Con | V0.5act (mV) ProTx II (1 μM) | Vh (mV) Con | Vh (mV) ProTx II (1 μM) |
hCav3.1 | 8.9 | -51.6 | -64.5** | -73.7 | -76.5 |
hCav3.2 | 29 | -49.4 | -52.1 | -64.2 | -76.5* |
hCav3.3 | 8.9 | -50.0 | -60.7 | -79 | -77 |
B | |||||
Clone | Current block (%) ProTxl (1 μM) | V 0.5 act (mV) Con | V 0.5 act (mV) ProTxl (1 μM) | Vh (mV) Con | Vh (mV) ProTxl (1 μM) |
hCav3.1 wt | 50 | -52.3 | -52.3 | -74 | -76 |
hCav3.2 wt | 8 | -52.6 | -58.8* | -64 | -75* |
hCav3.3 wt | 26* | -50.1 | -50.1 | -79 | -75 |