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Table 1 Summary of biophysical parameters of various T-type calcium channels in the absence or presence of A, 1 μM ProTx II and B, 1 μM ProTx I

From: Block of T-type calcium channels by protoxins I and II

A
Clone Current block (%) ProTx II (1 μM) V0.5act (mV) Con V0.5act (mV) ProTx II (1 μM) Vh (mV) Con Vh (mV) ProTx II (1 μM)
hCav3.1 8.9 -51.6 -64.5** -73.7 -76.5
hCav3.2 29 -49.4 -52.1 -64.2 -76.5*
hCav3.3 8.9 -50.0 -60.7 -79 -77
B
Clone Current block (%) ProTxl (1 μM) V 0.5 act (mV) Con V 0.5 act (mV) ProTxl (1 μM) Vh (mV) Con Vh (mV) ProTxl (1 μM)
hCav3.1 wt 50 -52.3 -52.3 -74 -76
hCav3.2 wt 8 -52.6 -58.8* -64 -75*
hCav3.3 wt 26* -50.1 -50.1 -79 -75
  1. Asterisks denote statistical significance relative to hCav3.2 [A] or hCav3.1 [B] for current block, or relative to wild type for all other parameters [*p < 0.05, **p < 0.01].