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Table 2 Summary of biophysical parameters of human Cav3.1, rat Cav3.1 and hCav3.1-hCav3.3 chimeras in the absence or presence of 1 μM ProTx I

From: Block of T-type calcium channels by protoxins I and II

Chimera Current block (%) ProTx I (1 μM) V0.5act (mV) Con V0.5act (mV) ProTx I (1 μM) Vh (mV) Con Vh (mV) ProTx I (1 μM)
hCav3.1 wt 50 -52.3 -52.3 -74 -76
GGGI 23** -43.5 -44.5 -75.3 -77.5
GIGG 43 -56.9 -49.0 # -76.1 -75.9
GIGI 16** -41.1 -33.5 # -73.2 -73.2
IGIG 50 -41.8 -34.6 # -68.9 -69.3
IGII 25* -42.5 -41.0 -74.0 -73.7
lIIG 35 -41.7 -38.8 -72.5 -73.7
rCav3.1 wt 60 -57.6 -54.2 -75.1 -80.9 #
  1. Asterisks denote statistical significance relative to hCav3.1 for current block. The hash tag denotes significance relative to control [#, *p < 0.05, **p < 0.01].