Table 2 Summary of biophysical parameters of human Cav3.1, rat Cav3.1 and hCav3.1-hCav3.3 chimeras in the absence or presence of 1 μM ProTx I
From: Block of T-type calcium channels by protoxins I and II
Chimera | Current block (%) ProTx I (1 μM) | V0.5act (mV) Con | V0.5act (mV) ProTx I (1 μM) | Vh (mV) Con | Vh (mV) ProTx I (1 μM) |
|---|---|---|---|---|---|
hCav3.1 wt | 50 | -52.3 | -52.3 | -74 | -76 |
GGGI | 23** | -43.5 | -44.5 | -75.3 | -77.5 |
GIGG | 43 | -56.9 | -49.0 # | -76.1 | -75.9 |
GIGI | 16** | -41.1 | -33.5 # | -73.2 | -73.2 |
IGIG | 50 | -41.8 | -34.6 # | -68.9 | -69.3 |
IGII | 25* | -42.5 | -41.0 | -74.0 | -73.7 |
lIIG | 35 | -41.7 | -38.8 | -72.5 | -73.7 |
rCav3.1 wt | 60 | -57.6 | -54.2 | -75.1 | -80.9 # |