Skip to main content
Figure 2 | Molecular Brain

Figure 2

From: Vorinostat positively regulates synaptic plasticity genes expression and spine density in HIV infected neurons: role of nicotine in progression of HIV-associated neurocognitive disorder

Figure 2

A hypothetical model for the role of eIF2α phosphorylation in translational repression of synaptic plasticity genes in HIV infected neuronal cells. In HIV infection, due to partial phosphorylation of eIF2α, general translation is reduced and ATF4 mRNA translation is augmented. As a consequence, the expression of synaptic plasticity and memory-related genes is blocked.

Back to article page

Molecular Brain

ISSN: 1756-6606