Increased HIV-infectivity rate of neuronal cells in the presence of nicotine. SK-N-MC cells were infected with HIV for 7 days with/without nicotine. Cells were harvested; RNA was isolated from the infected cells. LTR real-time PCR analysis indicated that HIV infectivity rate was significantly higher in the presence of nicotine than HIV alone infected cells. Significantly increased HIV infectivity (latency disruption) in vorinostat treated neuronal cells was also observed (not significant in combination with nicotine). (*, p ≤ 0.05; NS-Not Significant).