Table 1 Human synaptic plasticity genes expression in HIV infected neuronal cells and in combination with nicotine and/or vorinostat (fold change)

ADAM10 ^5,6,9

1.47

1.89

1.24

4.12

1.45

-1.03

1.11

ADCY1 ³

1.12

-3.39

1.12

-3.15

2.26

-3.99

1.17

ADCY8 ³

1.12

-3.39

1.12

-3.15

2.26

-3.99

-1.96

AKT1 ⁷

3.10

2.96

3.84

3.42

4.59

-1.32

4.23

ARC ^1,9

-1.09

1.30

1.54

1.07

2.79

-4.81

1.55

BDNF ^1,3

1.12

-3.39

1.12

-3.15

2.26

-3.99

-1.96

CAMK2A ³

1.12

-3.39

1.12

-3.15

2.26

-3.99

-1.96

CAMK2G ^3,7

1.48

1.11

1.46

1.16

1.62

-3.38

1.33

CDH2 ^3,5

1.12

-3.06

1.12

-3.15

2.26

-3.99

-1.37

CEBPB ¹

1.37

2.50

1.64

1.98

2.07

-3.07

2.04

CEBPD ¹

1.39

1.89

1.96

1.35

3.03

-3.07

1.96

CNR1 ³

1.12

-3.39

1.12

-3.15

2.26

-3.99

-1.96

CREM ¹

-35.90

-9.78

-15.78

-8.26

-16.02

-25.41

-16.77

EGR1 ¹

2.37

1.13

1.34

-5.68

1.15

-9.24

1.20

EGR2 ¹

6.89

1.94

4.29

9.22

3.34

1.43

2.43

EGR3 ¹

1.86

1.01

3.89

-1.76

2.94

-3.99

2.43

EGR4 ¹

-1.95

-6.69

-1.96

-3.20

1.03

-8.74

-4.28

EPHB2 ⁸

1.71

-2.97

1.74

-3.15

2.36

-3.99

1.43

FOS ¹

1.15

-1.24

1.07

1.07

1.43

-3.83

-1.12

GABRA5 ^3,8

1.91

-3.39

1.12

-1.62

2.26

-3.99

-1.96

GRIA1 ^3,4,8,9

1.12

-3.39

1.12

-3.15

2.26

-3.99

-1.96

GRIA2 ^3,4,8

4.04

2.38

2.55

2.09

4.40

1.10

3.49

GRIA4 ^4,8,9

12.85

9.24

4.35

2.39

5.73

-1.50

3.12

GRIN1 ^3,7,8,9

31.65

5.89

28.25

4.70

39.89

-1.02

35.80

GRIN2A ^3,5,7,8,9

2.26

-3.06

1.12

-2.14

2.26

-3.99

-1.07

GRIN2B ^3,5,7,8,9

2.26

-3.39

1.12

-3.15

2.26

-3.99

-1.07

GRIN2C ^3,7,8,9

2.26

-1.73

1.80

-3.15

2.26

-3.99

-1.07

GRIN2D ^3,7,8

4.25

1.42

2.17

4.97

4.25

-1.34

2.80

GRIP1 ⁴

3.07

-1.09

2.36

2.72

3.07

-1.90

1.96

GRM1 ^4,8,9

1.12

-3.39

1.12

-3.15

2.26

-3.99

-1.96

GRM2 ^4,8

1.85

1.93

1.12

3.79

2.26

-1.47

1.01

GRM3 ^8,9

1.12

-3.39

1.12

-2.11

2.26

-3.99

-1.96

GRM4 ⁸

2.26

-3.06

1.12

1.34

2.26

-3.99

-1.21

GRM5 ⁸

1.12

3.38

1.12

-1.15

2.26

-2.75

-1.96

GRM7 ⁸

1.12

-3.06

1.12

2.45

2.26

-2.33

-1.10

HOMER1 ^1,9

-1.64

-1.13

-2.95

1.30

-2.68

-1.93

-3.13

IGF1 ⁴

1.96

9.13

1.32

11.75

1.19

3.37

1.17

INHBA ²

4.15

-2.11

2.03

-1.43

2.22

-5.89

2.25

JUN ¹

8.84

-1.39

6.73

-1.65

8.04

-11.61

6.33

JUNB ¹

3.93

2.73

4.06

1.42

10.84

-3.97

3.79

KIF17 ¹⁰

2.30

-2.99

3.20

-1.89

4.19

-9.30

3.34

MMP9 ^1,3,6

3.06

-2.68

2.00

-2.94

2.99

-10.32

1.62

NCAM1 ⁵

1.17

-4.59

1.41

-6.80

1.40

-39.88

1.25

NFKB1 ¹

-20.48

-6.41

-35.26

-5.45

-26.76

-25.59

-48.77

NFKBIB ¹

9.61

12.91

13.09

14.56

14.20

13.54

13.66

NGF ^1,4

5.79

1.45

4.92

1.30

4.72

-3.01

6.55

NGFR ⁴

1.30

2.50

1.13

2.65

1.37

-2.18

1.04

NOS1 ⁴

1.12

-3.39

1.12

1.22

2.26

-3.99

-1.96

NPTX2 ¹

1.12

2.22

1.12

1.28

2.26

-3.29

3.19

NR4A1 ¹

5.11

1.47

6.73

2.54

4.82

-1.79

4.67

NTF3 ¹

1.12

-3.06

1.12

1.92

2.26

-1.53

-1.96

NTF4 ³

1.98

1.14

4.82

-1.30

5.85

-6.14

4.63

NTRK2 ³

1.12

-3.40

1.12

-3.15

2.26

-3.99

-1.96

PCDH8 ^1,5

2.37

2.53

1.29

3.37

2.04

-1.68

1.35

PICK1 ^4,9

1.58

1.54

2.64

1.18

2.65

-4.21

2.30

PIM1 ¹

11.19

4.86

25.46

10.59

33.08

2.55

32.95

PLAT ^1,4,6

-1.03

-1.82

-1.03

-2.34

1.97

-4.59

-2.25

PLCG1 ³

2.19

1.23

2.35

1.39

3.78

-3.62

2.91

PPP1CA ^3,4,7

-2.04

1.54

1.37

-1.69

1.16

-13.25

1.48

PPP1R14A ⁴

1.12

-3.06

1.12

-3.15

2.26

-3.99

-1.96

PPP2CA ⁴

6.52

10.06

6.87

13.31

7.20

3.28

6.64

PRKCA ^3,4

5.40

2.80

3.29

7.23

4.43

2.24

2.93

PRKCG ³

2.30

-5.07

2.16

-4.84

3.22

-6.62

2.12

PRKG1 ⁴

1.12

-3.06

1.12

-3.15

2.26

-3.99

-1.47

RAB3A ³

86.46

56.49

106.15

75.27

91.65

15.81

103.39

RELA ¹

1.30

2.00

1.34

3.26

1.45

-1.12

1.25

RELN ^5,6

1.12

-3.06

1.12

-3.15

2.26

-3.99

-1.96

RGS2 ¹

5.29

-1.40

2.62

-1.12

4.46

-2.90

2.38

RHEB ¹

-49.73

-32.90

-57.68

-35.16

-46.92

-84.30

-69.94

SIRT1 ¹⁰

2.29

2.58

1.91

4.70

1.89

1.52

1.28

SRF ¹

2.70

2.83

1.82

3.19

2.33

-1.44

1.60

TIMP1 ⁶

-18.20

-38.00

-20.11

-24.02

-15.69

-79.20

-17.73

TNF ^1,5

-2.65

-5.47

-2.28

-2.63

-1.42

-5.97

-9.30