Figure 8

ATX-II accelerates AISS induction at hippocampal GABAergic neurons. AISS is induced under the control and subsequent application of ATX-II (50 nM) after the first round of AISS disappears for 6 minutes, a time interval similar to Figure 1. A) illustrates AISS induction under the control (top trace) and in presence of ATX-II (bottom trace). Calibration bars are 20 mV and 10 seconds. B) shows dynamical changes in threshold potentials under the control (blue symbols) and in presence of ATX-II (red symbols). C) shows the number of spikes needed for AISS onset under the control (blue bar) and in presence of ATX-II (red bar; asterisk, p < 0.05, n = 8).