Figure 1
From: Transcriptomic evidence for immaturity of the prefrontal cortex in patients with schizophrenia
Comparison of gene expression patterns between the developing and adult schizophrenic prefrontal cortex (PFC). (a) The gene expression pattern in the dorsolateral frontal cortex (DLFC; Brodmann area [BA]46) of patients with schizophrenia (GSE21138, patients [26.1 ± 2.05 years] compared with controls [28.8 ± 2.55 years]) was compared with that in the DLFC (BA46) of normal infants (GSE13564, infants <2 years, compared to adults, 20–49 years). (b) The gene expression pattern in the DLFC (BA46) of patients with schizophrenia (GSE21138, patients compared with controls) was compared with that in the DLFC (BA9 and 46) of normal infants (GSE25219, infants, 1–5 years, compared with adults, 20–39 years). Note that microarray data sets of the normal developing DLFC were obtained from two independent research groups and were used in (a) and (b), respectively. (c) The gene expression pattern in the medial prefrontal cortex, (MFC) (BA10) of patients with schizophrenia (GSE17612, patients [73.3 ± 15.2 years] compared with controls [69.0 ± 21.6 years]) was compared with that in the MFC (BA24, 32, 33) of normal infants (GSE25219, infants, 1–5 years, compared with adults, 20–39 years).