Figure 3

Cell-type contributions to transcriptional immaturity in schizophrenic PFC. Genes showing the same directional changes in expression between the normal developing and adult schizophrenic PFC (a-d, Bioset1 in DLFC data set; e-h, Bioset2 in second DLFC data set; i-l, Bioset3 in MFC data set) were compared to those obtained from cell-type specific developmental experiments (a, e, i, FS neurons [GSE17806]; b, f, j, astrocytes [GSE9566]; c, g, k, oligodendrocytes [GSE9566]). Venn diagrams illustrate the overlap in transcriptome-wide gene expression changes between two conditions. Bonferroni correction was used to adjust the significant level by the number of pairs of datasets included in each study (see the Methods section and Additional file1: Table S27). Bar graphs illustrate the P-values of overlaps of genes upregulated (red arrows) or downregulated (blue arrows) by each condition, between the two conditions. Note that the scale of the y-axis is the same in a–c, e–g, and i–k. (d, h, l) Pie chart representing the percentage that each cell-type contributes to altered gene expression in Bioset1 (d), Bioset2 (h), and Bioset3 (l). Ast, astrocytes; FS, FS neurons; OL, oligodendrocytes.