Figure 4
From: Inorganic polyphosphate regulates neuronal excitability through modulation of voltage-gated channels
PolyP stimulates neurons and glia in hippocampal co-cultures. A) Addition of polyP causes immediate firing of neurons, with many of the cells having a secondary burst a few minutes later. B) PolyP evoked glia depolarization from the same experiment as A), showing concurrent activation of the glia. C) Glia activity corresponding to the neuronal firing in B), showing the presence of suramin resulted in delayed glial activity evoked by polyP.