Table 1 Mutant mice with enhanced memory

Excitatory synaptic transmission

NR2B (GluN2B) Tg

Enhanced in MWM, CFC, ORT, NMT

Enhanced CA1 LTP

[1–4]

Cdk5 cKO

Enhanced in CFC, reversal learning in MWM

Enhanced CA1 LTP

[5]

p25 Tg

Enhanced in MWM, CFC

Enhanced CA1 LTP

[6]

Kif17 Tg

Enhanced in MWM, DMT

Not determined

[7]

ORL1 KO

Enhanced in MWM, CFC, PA

Enhanced CA1 LTP

[8, 9]

Hgf Tg

Enhanced in MWM

Not determined

[10]

Ca _v β3 KO

Enhanced in MWM

Enhanced CA1 LTP

[11]

Dao KO

Enhanced in MWM

Enhanced CA1 LTP

[12]

Presynaptic function

H-ras Tg

Enhanced in MWM, CFC

Enhanced CA1, cortical LTP

[13]

Ncx2 KO

Enhanced in MWM, CFC, ORT

Enhanced CA1 LTP

[14]

Cbl-b KO

Enhanced in MWM (remote memory)

No change in CA1 LTP

[15]

Gap43 Tg

Enhanced in MWM

Enhanced CA1 LTP

[16]

Inhibitory synaptic transmission

GABA _A R α4 (Gabra4) KO

Enhanced in CFC, TFC

Not determined

[17]

Magl KO

Enhanced in MWM, ORT

Enhanced CA1 LTP

[18]

Pkr (Eif2ak2) KO

Enhanced in MWM, CFC, AFC

Enhanced CA1 LTP

[19]

GABA _A R α5 (Gabra5) KO

Enhanced in MWM

Trend of enhanced CA1 LTP

[20]

Grpr KO

Enhanced in CFC, AFC

Enhanced amygdala LTP

[21]

Network activity

Bec1 KO

Enhanced in MWM, YM

No change in CA1 LTP; Impaired LTP in Tg

[22]

Kvβ1.1 KO

Enhanced in MWM (aged mice only)

Enhanced CA1 LTP (aged mice only)

[23]

Hcn1 KO

Enhanced in MWM

Enhanced perforant path LTP

[24]

Transcriptional regulation and its upstream molecules

CREB-Y134F Tg

Enhanced in MWM, CFC, SR, CD

Enhanced CA1 LTP

[25]

CREB-DIEDML Tg

Enhanced in CFC, SR

Not determined

[25]

eIF2α^S51A KI

Enhanced in MWM, CFC, AFC

Enhanced CA1 LTP

[26]

Gcn2 KO

Enhanced in MWM, impaired in CFC

Enhanced CA1 LTP

[27]

ATF4, C/EBP CI

Enhanced in MWM

Enhanced CA1 LTP

[28]

CamkIV Tg

Enhanced in CFC

Enhanced CA1 LTP

[29]

Ac1 Tg

Enhanced in ORT

Enhanced CA1 LTP

[30]

Ap oa ₁ Tg

Enhanced in CFC, ORT

Enhanced CA1 LTP

[31]

Pde4d KO

Enhanced in MWM, RAM, ORT

Not determined, but see[32]

[33]

Pde8b KO

Enhanced in MWM, CFC

Not determined

[34]

Calcineurin CI

Enhanced in MWM, AFC, ORT

Enhanced CA1 LTP

[35, 36]

PP1 CI

Enhanced in MWM, ORT

Enhanced CA1 LTP

[37, 38]

Translational regulation

Paip2a KO

Enhanced in MWM, OLT, CFC

Enhanced CA1 L-LTP

[39]

Fkbp12 KO

Enhanced in CFC

Enhanced CA1 L-LTP

[40]

Epigenetic regulation

Hdac2 KO

Enhanced in CFC, AFC, NMT

Enhanced CA1 LTP

[41]

miRNA biogenesis

Dicer1 KO

Enhanced in MWM, CFC, TFC

Enhanced CA1 LTP

[42]

Extracellular molecules

Mmp9 Tg

Enhanced in MWM, ORT

Enhanced CA1 LTP

[43]

tPA (Plat) Tg

Enhanced in MWM

Enhanced CA1 LTP

[44]

HB-GAM (Ptn) Tg

Enhanced in MWM

Enhanced CA1 LTP

[45, 46]

Other manipulations

Ncs-1 Tg

Enhanced in MWM, ORT

Enhanced perforant path LTP

[47]

Rgs14 KO

Enhanced in MWM (learning), ORT

Enhanced CA2 LTP

[48]

5-HT ₃ R Tg

Enhanced in CFC

Not determined

[49]

Maoa KO

Enhanced in CFC, AFC

Not determined

[50]

Hdc KO

Enhanced in MWM, CFC, AFC

Enhanced CA1 LTP

[51, 52]

Def45 KO

Enhanced in MWM, ORT

Not determined

[53, 54]

EC-SOD Tg

Enhanced in MWM, impaired CFC

Enhanced CA1 LTP

[55]

S100b KO

Enhanced in MWM, CFC

Enhanced CA1 LTP

[56]