Figure 3

Behavioral assessment of zymosan-treated mice in the open field. (A) Counts of vertical, ambulatory, stereotypic and jump behaviors in zymosan-treated mice were decreased compared to saline-injected mice on days 1, 7, 14 and 28 day (n = 6 mice per group for each testing day). * denotes a significant difference between zymosan- and saline-treated mice. (B) Vertical, ambulatory, stereotypic and jump counts over 30 min on days 1, 7, 14 and 28 for zymosan-treated mice (n = 6 for each testing day) and saline-treated mice (n = 24 mice). (C) Representative traces show the movement of zymosan- and saline-treated mice in the open field test over a period of 30 min. (D) Zymosan-treated mice traveled significantly less distance than did saline-treated mice on days 1, 7, 14 and 28 (n = 6 mice per group for each testing day). * denotes a significant difference between zymosan- and saline-treated mice. (E) The distance traveled by zymosan-treated mice in the central zone within the first 5 min of the 30-min session of the open field test was significantly reduced on days 1, 7, 14 and 28 (n = 6 mice for each testing day) compared to saline-treated mice (n = 24 mice). * denotes a significant difference from saline-treated mice.