Figure 5
Effects of NB001 and gabapentin on visceral pain behaviors in zymosan-treated and naïve mice. The histogram shows that the number of visceral pain behaviors observed in zymosan-treated mice on days 1, 7, 14 and 28 decreased significantly after injection with NB001 (3 mg/kg, n = 6 mice) or gabapentin (30 mg/kg, n = 6 mice) compared to mice injected with saline (n = 6 mice). * denotes a significant difference compared to saline- injected mice. No significant difference was observed in the number of visceral pain behaviors among naïve mice administered NB001, gabapentin or saline (n = 6 mice per group; P = 0.87). Visceral pain was measured 45 min after IP injection.