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Figure 6 | Molecular Brain

Figure 6

From: Effects of NB001 and gabapentin on irritable bowel syndrome-induced behavioral anxiety and spontaneous pain

Figure 6

Effects of NB001 and gabapentin on spontaneous pain and anxiety-like behaviors in the open field. (A) Counts of vertical, ambulatory, stereotypic and jump behaviors in zymosan-treated mice on days 1, 7, 14 and 28 increased after injection of NB001 or gabapentin compared to saline injection (n = 6 mice per group for each testing day). * denotes a significant difference compared to saline- injected mice. (B) The distance traveled by zymosan-treated mice on days 1, 7, 14 and 28 increased after injection of NB001 or gabapentin compared to saline injection (n = 6 mice per group for each testing day). * denotes a significant difference compared to saline- injected mice. (C) Gabapentin injection significantly increased the distance traveled in the central zone within the first 5 min of the 30-min test session in zymosan-treated mice on days 1, 7, 14 and 28 compared to saline injection (n = 6 mice per group for each testing day). * denotes a significant difference compared to saline- injected mice. No significant difference was observed between zymosan-treated mice injected with NB001 or saline on testing days (P = 0.63). (D) Representative traces showed the movements of zymosan-treated mice injected with NB001, gabapentin or saline in the open field over a 30 min testing period on day 28. In each experiment, behavioral testing began 45 min after IP injection.

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