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Table 2 Effects of NB001 or gabapentin IP injection on spontaneous activities counts of zymosan-treated mice

From: Effects of NB001 and gabapentin on irritable bowel syndrome-induced behavioral anxiety and spontaneous pain

Counts

Day

Saline IP

NB001 IP

P

Gabapentin IP

P

Vertical

1

437.7 ± 44.4

612.3 ± 46.7

< 0.05

599.3 ± 50.4

< 0.05

 

7

437.3 ± 46.1

639.5 ± 44.8

< 0.01

646.2 ± 45.7

< 0.01

 

14

411.2 ± 46.6

600.2 ± 46.4

< 0.01

623.5 ± 51.8

< 0.01

 

28

400.3 ± 46.7

605.0 ± 43.9

< 0.01

621.0 ± 44.9

< 0.01

Ambulatory

1

1342.5 ± 197.6

2000.8 ± 199.2

< 0.05

1942.0 ± 193.9

< 0.05

 

7

1345.5 ± 224.19

2184.5 ± 214.7

< 0.01

2058.3 ± 205.0

< 0.05

 

14

1155.2 ± 211

2274.2 ± 208.5

< 0.001

2222.8 ± 212.1

< 0.001

 

28

985.3 ± 172.9

2210.8 ± 206.1

< 0.001

2289.8 ± 205.0

< 0.001

Stereotypic

1

3323.5 ± 252.9,

4214.0 ± 254.7

< 0.05

4418.0 ± 272.7

< 0.01

 

7

3039.7 ± 205.2

4038.2 ± 271.3

< 0.05

3944.3 ± 306.2

< 0.05

 

14

3103.7 ± 264.8

4002.7 ± 280.8

< 0.05

3885.7 ± 280.8

< 0.05

 

28

2895.2 ± 296.9

3904.0 ± 253.4

< 0.05

3920.2 ± 258.4

< 0.01

Jump

1

55.7 ± 5.3

79.0 ± 5.7

< 0.01

84.2 ± 7.2

< 0.01

 

7

60.3 ± 4.9

84.8 ± 4.7

< 0.01

82.0 ± 6.9

< 0.01

 

14

60.5 ± 5.61

82.2 ± 5.8

< 0.01

88.8 ± 5.2

< 0.01

 

28

63.8 ± 5.7

89.7 ± 5.4

< 0.01

85.8 ± 5.6

< 0.01

  1. P: in comparison with saline IP injection group; n = 6 mice per group.