Figure 3

Behavioral battery in Adar2^+/−mice. a,b) Open-field test. The vertical axis is the counts measured by the interruption of infrared beams. a) Locomotor activity. b) Rearing. Closed circles indicate the Adar2^+/− mice (+/−). Open circles indicate the WT mice (+/+). No significant genotype × time interaction was found for locomotor activity. Locomotor count tended to be higher in the Adar2^+/− mice than that in the WT mice (t = 2.0, P = 0.05). RMANOVA with the intrasubject factor of time (1–20 min, df = 19) and the intersubject factor of genotype showed no significant effect of genotype or genotype × time interaction in rearing count. c) PPI test. There was no significant difference between genotypes. d, e) Elevated plus maze test. d) Number of entries to open arms. e) Time spent on open arms. There was no significant difference in the number of entries and time spent on open arms between genotypes. f, g) Morris water maze test. f) Escape latency. No significant effect of genotype was found for the escape latency by RMANOVA. g) Probe test. There was no significant difference between genotypes. h) Passive avoidance test. There was no significant effect of genotypes by two-way ANOVA. i, j) Active avoidance test. There was no significant interaction between time (df = 14) and genotype (df = 1) in the avoidance latency (i) or number of avoidances (j) by RMANOVA (P = 0.05). k, l) Forced swimming test. k) Duration of immobility. l) The ratio of immobility time on the second day to the first day. Data represent mean and error bars indicated by standard errors (n = 16 for each genotype).