A role of ADAR2 and RNA editing of glutamate receptors in mood disorders and schizophrenia

Table 2 Expression levels of ADARs in postmortem brains of patients with mental disorders

Array collection samples
	All samples (normalized by GAPDH)		All samples (normalized by CFL1)
Diagnosis	ADAR1	ADAR2	ADAR1	ADAR2
Bipolar disorder	0.0219 ± 0.0090	0.0025 ± 0.0011	0.0397 ± 0.0163	0.0046 ± 0.0018^b)
Schizophrenia	0.0216 ± 0.0086	0.0024 ± 0.0008^a)	0.0393 ± 0.0192	0.0043 ± 0.0015^c)
Control	0.0232 ± 0.0063	0.0029 ± 0.0009	0.0477 ± 0.0380	0.0054 ± 0.0015
One-way ANOVA	NS	F = 2.11, P = 0.120	NS	F = 3.86, P = 0.024
	pH-adjusted (normalized by GAPDH)		pH-adjusted (normalized by CFL1)
Diagnosis	ADAR1	ADAR2	ADAR1	ADAR2
Bipolar disorder	0.0028 ± 0.0010	0.0244 ± 0.0096	0.0050 ± 0.0016	0.0442 ± 0.0180
Schizophrenia	0.0025 ± 0.0008^d)	0.0231 ± 0.0088	0.0043 ± 0.0013^e)	0.0401 ± 0.0149
Control	0.0031 ± 0.0008	0.0238 ± 0.0054	0.0054 ± 0.0014	0.0420 ± 0.0080
One-way ANOVA	F = 3.09, P = 0.052	NS	F = 4.37, P = 0.016	NS
Neuropathology Consortium Samples
	Normalized by GAPDH		Normalized by CFL1
Diagnosis	ADAR1	ADAR2	ADAR1	ADAR2
Bipolar disorder	0.0025 ± 0.0016^f)	0.0110 ± 0.0071	0.0122 ± 0.0097	0.0026 ± 0.0017^g)
Depression	0.0030 ± 0.0012	0.0107 ± 0.0036	0.0043 ± 0.0013^e)	0.0039 ± 0.0012
Schizophrenia	0.0029 ± 0.0006	0.0107 ± 0.0045	0.0151 ± 0.0051	0.0039 ± 0.0010
Control	0.0033 ± 0.0008	0.0119 ± 0.0054	0.0133 ± 0.0062	0.0037 ± 0.0010
One-way ANOVA	NS	NS	NS	F = 5.6, P = 0.008

Values are given in ± mean SD.
^a)t = 2.22, P = 0.029 to control, ^b)t = -1.92, P = 0.05 to control.
^c)t = 2.90, P = 0.005 to control, ^d)t = -2.65, P = 0.01, ^e)t = -3.12, P = 0.003.
^f)t = -1.70, P = 0.09 to control, ^g)t = -2.0, P = 0.06 to control.
NS: not significant.
For one of 13 subjects with schizophrenia in Neuropathology Consortium, data was missing.

ISSN: 1756-6606