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Table 1 G-protein isoforms

From: How much do we know about the coupling of G-proteins to serotonin receptors?

Protein name Gene name Validated at protein level Validated at transcript level
G alpha proteins
Gαi1 GNAI1 2 -
Gαi2 GNAI2 4 6
Gαi3 GNAI3 1 -
Gα11 GNA11 1 -
Gα12 GNA12 1 5
Gα13 GNA13 1 2
Gα14 GNA14 - 1
Gα15 (or Gα16) GNA15 1 2
Gαolf GNAL 3 1
Gαo GNAO 2 1
Gαq GNAQ 1 2
Gαs GNAS 7 4
Gαt1 GNAT1 1 -
Gαt2 GNAT2 1 -
Gαt3 GNAT3 - 1
Gαz GNAZ - 2
G beta proteins
Gβ1 GNB1 1 2
Gβ1-like GNB1L 1 1
Gβ2 GNB2 1 2
Gβ2-like GNB2L1 1 17
Gβ3 GNB3 1 3
Gβ4 GNB4 1 1
Gβ5 GNB5 3 3
G gamma proteins
Gγ1 GNGT1 - 2
Gγ2 GNG2 1 5
Gγ3 GNG3 - 1
Gγ4 GNG4 1 -
Gγ5 GNG5 1 -
Gγ7 GNG7 1 1
Gγ8 GNG8 (alias GNG9) - 1
Gγ10 GNG10 1 -
Gγ11 GNG11 1 -
Gγ12 GNG12 1 -
Gγ13 GNG13 - 1
Gγt2 GNGT2 (alias GNG8 or GNG9) - 2
  1. For each human G-protein, it is shown the number of the related isoforms subdivided by the validation status, according to UniProt. Note that, GNA15 is the homolog gene encoding the murine Gα15 and the human Gα16 [[13]].