Figure 1

Typical bursting patterns and AP parameters of bursting pacemakerneuron. (A) Bursting patterns of bursting pacemaker neuron; membrane potentialvs. time. The electrophysiological parameters related to burst firing containthe intraburst interspike interval, the duration between the two points ofsequential V_pp within one burst firing event [A (1)];interburst interval, the duration between the two points of the lastV_pp of one burst firing event and the first V_pp ofnext burst firing event [A (2)]; and burst duration, the durationbetween the two points of the first V_pp and the last V_ppwithin one burst firing event [A (3)]. (B) Definition of APparameters. The maximum point T on the upper part of AP means a positive peakmembrane potential, V_pp and the minimum point B on the lower part ofAP means a negative peak membrane potential, V_np. H1 and H2 meansthe half point of potential difference during the rising phase and the fallingphase of AP, respectively. The last half of the rising phase,Δt_r2 designate the time intervals between the two point H1and T. The first half of the falling phase of AP, Δt_f1 isdefined as the time interval between point T and point H2. The angleθ₁ shows the inverse tangent of the ratio of halfA_AP to Δt_r2 and angle θ2 means the inversetangent of the ratio of half A_AP to Δt_f1.